N-containing compounds from Broussonetia papyrifera seeds and their cAMP regulatory activity in N1E-115 cells

From the n -BuOH extract of Broussonetia papyrifera seeds, a novel chushizilactam A ( 1 ) and adenosine ( 2 ) were isolated. Compound 1 was identified as 5ζ-hydroxy-5-(hydroxymethyl)-4-methyl-3-vinyl-1 H -pyrrol2(5 H )-one. Compounds 1 and 2 were evaluated for their cAMP-regulating activity by the A...

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Bibliographic Details
Published in:Chemistry of natural compounds 2011-11, Vol.47 (5), p.783-785
Main Authors: Mei, Ren-Qiang, Wang, Xiang-Tao, Chen, Rui, Luo, Huai-Rong, Cheng, Yong-Xian
Format: Article
Language:English
Subjects:
Medicine
Organic Chemistry
Pharmacy
Plant Sciences
Seeds
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Summary:From the n -BuOH extract of Broussonetia papyrifera seeds, a novel chushizilactam A ( 1 ) and adenosine ( 2 ) were isolated. Compound 1 was identified as 5ζ-hydroxy-5-(hydroxymethyl)-4-methyl-3-vinyl-1 H -pyrrol2(5 H )-one. Compounds 1 and 2 were evaluated for their cAMP-regulating activity by the AlphaScreen assay against N1E-115 cells.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-011-0058-3