New Opportunities for the Synthesis of Quinoxaline-Substituted Heterocyclic and Aryl Moieties

6.7-Difluoroquinoxaline ( I ) reacted with dimedone, indandione, and 3-methyl-1-phenylpyrazol-5-one in DMSO solution in the presence of acid to form mono-substituted products IIa – c . Heating I with resorcinol in EtOH in the presence of acid gave resorcinol derivative IId . 6.7-Difluoroquinoxaline...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2013-12, Vol.47 (9), p.498-502
Main Authors: Azev, Yu. A., Kodess, M. I., Ezhikova, M. A., Gibor, A. M., Baranov, V. I., Ermakova, O. S., Bakulev, V. A.
Format: Article
Language:English
Subjects:
Drug Synthesis Methods and Manufacturing Technology
Hydrogen
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Pyridine
Substitution reactions
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Summary:6.7-Difluoroquinoxaline ( I ) reacted with dimedone, indandione, and 3-methyl-1-phenylpyrazol-5-one in DMSO solution in the presence of acid to form mono-substituted products IIa – c . Heating I with resorcinol in EtOH in the presence of acid gave resorcinol derivative IId . 6.7-Difluoroquinoxaline in the presence of base reacted with 3-methyl-1-phenylmethylpyrazol-5-one to form dipyrazolylmethane III and tetrapyrazolylethane derivative IV . Heating products IIa – c with N -methylpiperazine produced 7-methylpiperazine derivatives Va – c of 2-substituted quinoxalines.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-013-0989-z