Using rheology for optimization of adsorptive vaginal gel technology

The quality assurance system of soft medicinal preparations (SMPs) is based on standardization of the rheological parameters of compositions used in clinical practice. These rheological parameters influence the quality of pharmacological action. Biopharmaceutical studies demonstrate that the rheolog...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2010-11, Vol.44 (7), p.387-390
Main Authors: Romanko, T. V, Ayupova, G. V, Fedotova, A. A, Murinov, Yu. I, Romanko, V. G
Format: Article
Language:English
Subjects:
adsorptive vaginal gel
composition optimization
Maleic anhydride
Mechanical properties
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
rheological optimum of extrusion
soft medicinal preparations
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Summary:The quality assurance system of soft medicinal preparations (SMPs) is based on standardization of the rheological parameters of compositions used in clinical practice. These rheological parameters influence the quality of pharmacological action. Biopharmaceutical studies demonstrate that the rheological properties of SMPs are closely correlated with the intensity of the drug release and absorption. The structural and mechanical properties of an adsorptive vaginal gel based on styrene copolymer with maleic anhydride have been studied. The active substance was the adsorbent “Enterosgel.” Rheological data were used to determine the optimum combination of active substance and structural component concentrations in preparing the adsorptive gel composition.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-010-0473-y