Synthesis, characterization and biological evaluation of some novel 2-substituted mercaptobenzimidazole derivatives

Synthesis and biological assessment of six novel 2-substituted mercaptobenzimidazole derivatives is performed. The title compounds are characterized by their analytical and spectral data. All the synthesized compounds are screened for their anti-ulcer and anti-microbial activity. 2-(1H-benzimidazole...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2011-02, Vol.44 (11), p.642-645
Main Authors: Srinivas Reddy, Malladi, Nath Anisetti, Ravinder, Durga Prasad, K., Sannigrahi, Santanu, Arvinda Reddy, P.
Format: Article
Language:English
Subjects:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:Synthesis and biological assessment of six novel 2-substituted mercaptobenzimidazole derivatives is performed. The title compounds are characterized by their analytical and spectral data. All the synthesized compounds are screened for their anti-ulcer and anti-microbial activity. 2-(1H-benzimidazole-2-sulfinyl) –N-(4-benzyloxy-phenyl)-acetamide, N-(4-benzyloxy-phenyl)-4-(1H-benzimidazole-2-sulfinyl)-butyramide, N-(4-benzyloxy phenyl)-4-(5-methoxy 1H-benzimidazole-2-sulfinyl)-butyramide showed significant antiulcer activity. All the compounds moderate antibacterial and antifungal activity.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-011-0537-7