Synthesis and antitumor activity of new furyl-2-substituted 1,3,4-thiadiazoles and 1,2,4-triazoles

A series of new furyl-2-substituted derivatives of 1,3,4-thiadiazole and 1,2,4-triaozle have been synthesized. The S-alkylation and aminomethylation of the latter leading to their 3-mercapto- and 2-aminomethylene-substituted derivatives have been studied. Results of antitumor activity testing of the...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2012-03, Vol.45 (12), p.705-708
Main Authors: Ovsepyan, T. R., Grboyan, S. V., Arsenyan, F. G., Melik-Ogandzhanyan, R. G.
Format: Article
Language:English
Subjects:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Search for New Drugs
Triazoles
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Summary:A series of new furyl-2-substituted derivatives of 1,3,4-thiadiazole and 1,2,4-triaozle have been synthesized. The S-alkylation and aminomethylation of the latter leading to their 3-mercapto- and 2-aminomethylene-substituted derivatives have been studied. Results of antitumor activity testing of the synthesized compounds are presented and discussed.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-012-0706-3