Diagnostics of living cells under an atomic force microscope using a submicron spherical probe with a calibrated radius of curvature

The relief and mechanical elasticity of living cells from lines A549 and L41 are studied. To minimize the destructive effect of the atomic force microscope on the cell and improve the measuring accuracy of the elasticity module, special probes with a single colloid amorphous SiO 2 nanogranule at the...

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Bibliographic Details
Published in:Technical physics 2012-10, Vol.57 (10), p.1430-1437
Main Authors: Nyapshaev, I. A., Ankudinov, A. V., Stovpyaga, A. V., Trofimova, E. Yu, Eropkin, M. Yu
Format: Article
Language:English
Subjects:
Classical and Continuum Physics
Experimental Instruments and Technique
Physics
Physics and Astronomy
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Summary:The relief and mechanical elasticity of living cells from lines A549 and L41 are studied. To minimize the destructive effect of the atomic force microscope on the cell and improve the measuring accuracy of the elasticity module, special probes with a single colloid amorphous SiO 2 nanogranule at their tips are employed. A procedure for preparing such probes is demonstrated.
ISSN:1063-7842
1090-6525
DOI:10.1134/S1063784212100167