Synthesis and Biological Evaluation of New Bis-Indolyl (3-O-Benzyl-1,2-O-Isopropylidenexylopentadialdose-α-D-Glucofuranose)

3-O-benzyl-1,2-O-isopropylidene-xylopentadialdose has emerged as structurally new antibacterial and anti-inflammatory agent. Therefore, various substituted bis-indolyl- (3-O-benzyl-1,2-O-isopropylidene-xylopentadialdose glucofuranose) derivatives were synthesized by addition of substituted xylopenta...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2014, Vol.47 (10), p.544-548
Main Authors: Shankar, M., Balasubramaniam, A., Gowrishankar, N. L., Mahendran, S.
Format: Article
Language:English
Subjects:
Medicine
Methane
Nuclear magnetic resonance spectroscopy
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:3-O-benzyl-1,2-O-isopropylidene-xylopentadialdose has emerged as structurally new antibacterial and anti-inflammatory agent. Therefore, various substituted bis-indolyl- (3-O-benzyl-1,2-O-isopropylidene-xylopentadialdose glucofuranose) derivatives were synthesized by addition of substituted xylopentadialdose with various substituted indoles. The structures of the synthesized compounds were characterized by IR, 1 H NMR, 13 C NMR, and mass spectroscopy techniques. All the synthesised compounds showed maximum zone of inhibition againt both Gram-positive and Gram-negative organisms. In the anti-inflammatory activity test, three compounds ( 1 , 3 and 5 ) produced significant activity in a dose-dependent manner.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-014-1001-2