The Synthesis and Cytotoxic Properties of Selenopheno[3,2-c]- and Selenopheno-[2,3-c]quinolones

We have developed a method for the synthesis of novel selenophene-containing polycyclic heterocycles, derivatives of selenopheno[3,2- c ]- and selenopheno[2,3- c ]quinolones. The cytotoxic activity of these compounds was studied in vitro. The molecular structure of 3-bromo-5-methyl-2-(piperidin-2-yl...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2014-02, Vol.49 (11), p.1674-1680
Main Authors: Arsenyan, P., Vasiljeva, J., Shestakova, I., Domracheva, I., Belyakov, S.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
Pharmacy
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Summary:We have developed a method for the synthesis of novel selenophene-containing polycyclic heterocycles, derivatives of selenopheno[3,2- c ]- and selenopheno[2,3- c ]quinolones. The cytotoxic activity of these compounds was studied in vitro. The molecular structure of 3-bromo-5-methyl-2-(piperidin-2-ylmethyl)selenopheno[3,2- c ]quinolin-4(5H)-one was confirmed by X-ray analysis.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-014-1419-1