Studies of the Hydrolysis of Hesperidin

A variety of hydrolytic mixtures for the cleavage of glycoside bonds in hesperidin was studied. The optimum system for complete hydrolysis of hesperidin to prepare the aglycone consisted of CH 3 COOH, H 2 SO 4 , and C 2 H 5 OH at a ratio of 1:1:9. Studies of the kinetics of the hesperidin hydrolysis...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2014-02, Vol.47 (11), p.606-609
Main Authors: Evseeva, O. S., Andreeva, O. A., Oganesyan, É. T.
Format: Article
Language:English
Subjects:
Hydrolysis
Medicine
Methods of Drug Synthesis and Drug Production Technology
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:A variety of hydrolytic mixtures for the cleavage of glycoside bonds in hesperidin was studied. The optimum system for complete hydrolysis of hesperidin to prepare the aglycone consisted of CH 3 COOH, H 2 SO 4 , and C 2 H 5 OH at a ratio of 1:1:9. Studies of the kinetics of the hesperidin hydrolysis reaction in this system showed that the process was a first-order reaction, as demonstrated by the constant k . The maximum aglycone yield over time, 98%, was obtained by boiling the reaction mix for 8.5 h. This confirmed the suitability of our model. Prepared of hesperidin-7-O-glucoside should be by fractional hydrolysis in a system consisting of CH 3 COOH, H 2 SO 4 , and C 2 H 5 OH at a ratio of 1:1:9.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-014-1018-6