Biodistribution and toxicity assessment of radiolabeled and DMSA coated ferrite nanoparticles in mice

• Published in: Journal of radioanalytical and nuclear chemistry 2012-09, Vol.293 (3), p.915-921
• Main Authors: Fatahian, S., Shahbazi-Gahrouei, D., Pouladian, M., Yousefi, M. H., Amiri, Gh. R., Noori, A.
• Format: Article
• Language: English
• Subjects: Chemistry; Chemistry and Materials Science; Diagnostic Radiology; Hadrons; Heavy Ions; Inorganic Chemistry; Iron compounds; Nanoparticles; Nuclear Chemistry; Nuclear Physics; Physical Chemistry
• ISSN: 0236-5731; 1588-2780
• DOI: 10.1007/s10967-012-1822-y

DMSA-coated Fe 3 O 4 nanoparticles were synthesized by wet-chemical method. The chemical interaction between Fe 3 O 4 and DMSA were investigated by FTIR. They were directly radiolabeled with 99m Tc radioisotope (Fe 3 O 4 @DMSA– 99m Tc) at room temperature in the presence of stannous solution as a reducing agent. Magnetic and structure properties of Fe 3 O 4 @DMSA– 99m Tc nanoparticles were investigated by AGFM, TEM, and XRD. Biodistribution and toxicity assessment of Fe 3 O 4 @DMSA– 99m Tc were studied in mice by intravenous and intraperitoneally injections, respectively. Blood, kidney, and liver factors were measured 4 days post injection and at the mean-while tissue sections were prepared from their kidney and liver. The results indicate that, the Fe 3 O 4 @DMSA– 99m Tc nanoparticles were passed through the membrane of different cells but do not create any disorder in the kidney and liver function even in high doses such as 300 mg/kg.