Preparation and the biodistribution study of [[sup.131]I]-5,10,15,20tetrakis10,15,20-triphenylporphyrin

[[sup.131]I]-5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin and [[sup.131]I]-5-(4-aminophenyl)-10,15,20-triphenylporphyrin ([sup.131]I-TPPOH and [sup.131]I-TPPN[H.sub.2]) were prepared and their biodistribution properties were evaluated in normal Kunming (KM) mice and SMMC-7721 tumor-bearing BALB/c m...

Full description

Saved in:
Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2014-10, Vol.302 (1), p.123
Main Authors: Sun, Zhi-Zhong, Wei, Hong-Yuan, Wang, Guan-Quan, Zhou, Zhi-Jun, He, Jia-Heng, Wang, Jing, Luo, Shun-Zhong
Format: Article
Language:English
Subjects:
Porphyrins
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[[sup.131]I]-5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin and [[sup.131]I]-5-(4-aminophenyl)-10,15,20-triphenylporphyrin ([sup.131]I-TPPOH and [sup.131]I-TPPN[H.sub.2]) were prepared and their biodistribution properties were evaluated in normal Kunming (KM) mice and SMMC-7721 tumor-bearing BALB/c mice. The optimized labeling yields were 98 and 96 % for [sup.131]I-TPPOH and [sup.131]I-TPPN[H.sub.2], respectively. They were stable in vitro saline and in vivo. Both compounds had a specific affinity to liver and lung, and mainly metabolized through liver. They showed a time-dependent accumulation and retainable characteristics in SMMC-7721 tumor. These results supported their potential value for targeted tumor therapy agents. Keywords Porphyrin * Radiolabeling * [sup.131]I * Biodistribution
ISSN:0236-5731
DOI:10.1007/s10967-014-3269-9