Synthesis of Substituted 2-Pyridones Using Arylamidoesters of Malonic Acid

With the aim of developing of the new methods for the synthesis of substituted 2-pyridones, the reaction of arylamidoesters of malonic acid with ethoxymethylideneacetylacetone in the presence of triethylamine in ethanol solution was studied. NMR spectroscopy and X-ray diffraction structural analysis...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2014-11, Vol.50 (8), p.1126-1132
Main Authors: Hayotsyan, S. S., Hasratyan, A. H., Kon’kova, S. G., Khachatryan, A. Kh, Ayvazyan, A. E. Badasyan, A. G., Panosyan, G. A., Sargsyan, M. S.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Nuclear magnetic resonance spectroscopy
Organic Chemistry
Pharmacy
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Summary:With the aim of developing of the new methods for the synthesis of substituted 2-pyridones, the reaction of arylamidoesters of malonic acid with ethoxymethylideneacetylacetone in the presence of triethylamine in ethanol solution was studied. NMR spectroscopy and X-ray diffraction structural analysis of the reaction product indicated that the forming enedione undergoes the Michael reaction to provide substituted 2-pyridones.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-014-1572-6