Molecular Complexes of ivy and Licorice Triterpene Glycosides with Doxorubicin

The complexation of doxorubicin hydrochloride with the triterpene glycosides α-hederin [hederagenin 3- O -α-L-rhamnopyranosyl-(1→2)- O -α-L-arabinopyranoside], hederasaponin C [hederagenin 3- O -α-Lrhamnopyranosyl-(1→2)- O -α-L-arabinopyranosyl-28- O -α-L-rhamnopyranosyl-(1→4)- O -β-D-glucopyrano sy...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2014-09, Vol.48 (6), p.391-394
Main Authors: Yakovishin, L. A., Grishkovets, V. I., Klimenko, A. V., Degtyar, A. D., Kuchmenko, E. B.
Format: Article
Language:English
Subjects:
Anthracyclines
Medicinal Plants
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:The complexation of doxorubicin hydrochloride with the triterpene glycosides α-hederin [hederagenin 3- O -α-L-rhamnopyranosyl-(1→2)- O -α-L-arabinopyranoside], hederasaponin C [hederagenin 3- O -α-Lrhamnopyranosyl-(1→2)- O -α-L-arabinopyranosyl-28- O -α-L-rhamnopyranosyl-(1→4)- O -β-D-glucopyrano syl-(1→6)- O -β-D-glucopyranoside), and glycyram (monoammonium glycyrrhizate) in aqueous solutions at pH 7.2 was investigated using spectrophotometry. These glycosides formed 1:1 complexes with doxorubicin. The complex stability constants were determined.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-014-1117-4