The correlation of Tim-3 and IFN-γ expressions in mice infected with Toxoplasma gondii during gestation

The immunoinhibitory receptor T cell immunoglobulin domain and mucin domain-1 (Tim-1) and Tim-3 participate in the regulation of Th immune response as well as innate immunity. However, there is no report about the expression of Tim genes in Toxoplasma gondii-infected experimental models during pregn...

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Bibliographic Details
Published in:Parasitology Research 2015, p.125
Main Authors: Fu, Xiaoyin, Wu, Bin, Huang, Bo, Zheng, Huanqin, Huang, Shiguang, Gan, Yan, Shen, Jilong, Lun, Zhao-Rong, Lu, Fangli
Format: Report
Language:English
Subjects:
Health aspects
Host-bacteria relationships
Identification and classification
Immunoglobulins
Interferon
Pregnancy
T cells
Toxoplasma
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Summary:The immunoinhibitory receptor T cell immunoglobulin domain and mucin domain-1 (Tim-1) and Tim-3 participate in the regulation of Th immune response as well as innate immunity. However, there is no report about the expression of Tim genes in Toxoplasma gondii-infected experimental models during pregnancy. In this study, Kunming outbred pregnant mice were infected with RH strain of T gondii through vagina at days 10 to 16 of gestation, and the mRNA expressions of Tim-1, Tim-3, interleukin (IL)-4, and interferon (IFN)-γ in the placentas, uteri, and draining lumber aortic lymph nodes (LALNs) at day 18 of gestation were analyzed using quantitative real-time PCR (qRT-PCR). Compared with uninfected pregnant controls, significantly increased levels of IFN-γ and Tim-3 were detected in the placentas (P
ISSN:0932-0113
DOI:10.1007/s00436-014-4167-3