Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging: a potential utility for the evaluation of regional liver function impairment following transcatheter arterial chemoembolization

• Published in: Oncology Letters 2015, p.1191
• Main Authors: Xiao, Yu-Dong, Paudel, Ramchandra, Liu, Huan, Zhang, Bin, Ma, Cong, Zhou, Shun-Ke
• Format: Report
• Language: English
• Subjects: Antimitotic agents; Antineoplastic agents; Gadolinium; Medical research; Medicine, Experimental; Therapeutic chemoembolization
• ISSN: 1792-1074
• DOI: 10.3892/ol.2014.2826

The present study aimed to evaluate regional liver function impairment following transcatheter arterial chemoembolization (TACE), assessed by magnetic resonance imaging (MRI) enhanced by gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA). Additionally, this study evaluated the associations between signal intensity and various clinical factors. A prospective study was conducted between March 2012 and May 2013 with a total of 35 patients. Gd-EOB-DTPA-enhanced MRI was performed 3-5 days after TACE therapy. The signal to noise ratio (SNR) was subsequently calculated for healthy liver tissue regions and peritumoral regions, prior to and 20 min after Gd-EOB-DTPA administration. The correlation between clinical factors and relative SNR was assessed using Pearson's correlation coefficient or Spearman's rank correlation coefficient. Prior to Gd-EOB-DTPA administration, the SNR values showed no significant difference (t = 1.341, P=0.191) in healthy liver tissue regions (50.53 ± 15.99; range, 11.25-83.46) compared with peritumoral regions (49.81 ± 15.85; range, 12.34-81.53). On measuring at 20 min following Gd-EOB-DTPA administration, the SNR in healthy liver tissue regions (82.55 ± 33.33; range, 31.45-153.02) was significantly higher (t=3.732, P