Treatment with Rhizoma Dioscoreae extract has protective effect on osteopenia in ovariectomized rats

The aims of this study were to evaluate the osteoprotective effect of aqueous extract from Rhizoma Dioscoreae (RDE) on rats with ovariectomy- (OVX-) induced osteopenia. Our results show that RDE could inhibit bone loss of OVX rats after a 12-week treatment. The microarray analysis showed that 68 gen...

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Published in:The Scientific World Journal 2014, Vol.14
Main Authors: Zhang, Zhiguo, Xiang, Lihua, Bai, Dong, Fu, Xiaowei, Wang, Wenlai, Li, Yan, Liu, Hong, Pan, Jinghua, Li, Ya'nan, Xiao, Gary Guishan, Ju, Dahong
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Language:English
Subjects:
Care and treatment
Health aspects
Materia medica, Vegetable
Osteopenia
Ovariectomy
Patient outcomes
Plant extracts
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container_title The Scientific World Journal
container_volume 14
creator Zhang, Zhiguo
Xiang, Lihua
Bai, Dong
Fu, Xiaowei
Wang, Wenlai
Li, Yan
Liu, Hong
Pan, Jinghua
Li, Ya'nan
Xiao, Gary Guishan
Ju, Dahong
description The aims of this study were to evaluate the osteoprotective effect of aqueous extract from Rhizoma Dioscoreae (RDE) on rats with ovariectomy- (OVX-) induced osteopenia. Our results show that RDE could inhibit bone loss of OVX rats after a 12-week treatment. The microarray analysis showed that 68 genes were upregulated and that 100 genes were downregulated in femurs of the RDE group rats compared to those in the OVX group. The Ingenuity Pathway Analysis (IPA) showed that several downregulated genes had the potential to code for proteins that were involved in the Wnt/β-catenin signaling pathway (Sost, Lrp6, Tcf7l2, and Alpl) and the RANKL/RANK signaling pathway (Map2k6 and Nfatc4). These results revealed that the mechanism for an antiosteopenic effect of RDE might lie in the synchronous inhibitory effects on both the bone formation and the bone resorption, which is associated with modulating the Wnt/β-catenin signaling and the RANKL/RANK signaling.
doi_str_mv 10.1155/2014/645975
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source Wiley-Blackwell Open Access Collection; Publicly Available Content Database; PubMed Central
subjects Care and treatment
Health aspects
Materia medica, Vegetable
Osteopenia
Ovariectomy
Patient outcomes
Plant extracts
title Treatment with Rhizoma Dioscoreae extract has protective effect on osteopenia in ovariectomized rats
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