The Impact of Prophylactic Dexamethasone on Nausea and Vomiting after Thyroidectomy: A Systematic Review and Meta-Analysis

Background We carried out a systematic review and meta-analysis to evaluate the impact of prophylactic dexamethasone on post-operative nausea and vomiting (PONV), post-operative pain, and complications in patients undergoing thyroidectomy. Methods We searched Pubmed, Embase, and Cochrane Library dat...

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Bibliographic Details
Published in:PLoS ONE 2014, Vol.9 (10)
Main Authors: Zou, Zhenhong, Jiang, Yuming, Xiao, Mingjia, Zhou, Ruiyao
Format: Report
Language:English
Subjects:
Analgesics
Analysis
Blood glucose
Central nervous system depressants
Complications and side effects
Dexamethasone
Drug therapy
Gastrointestinal agents
Nausea
Weapons of mass destruction
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Summary:Background We carried out a systematic review and meta-analysis to evaluate the impact of prophylactic dexamethasone on post-operative nausea and vomiting (PONV), post-operative pain, and complications in patients undergoing thyroidectomy. Methods We searched Pubmed, Embase, and Cochrane Library databases for randomized controlled trials (RCTs) that evaluated the prophylactic effect of dexamethasone versus placebo with or without other antiemetics for PONV in patients undergoing thyroidectomy. Meta-analyses were performed using RevMan 5.0 software. Results Thirteen RCTs that considered high quality evidence including 2,180 patients were analyzed. The meta-analysis demonstrated a significant decrease in the incidence of PONV (RR 0.52, 95% CI 0.43 to 0.63, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0109582