Synthesis and Structure of 2-Nitroxyethylsuccinylaminodiethylmalonate

Interaction of hydroxymethylnitrodiethylmalonate with ammonia produced, in contrast to published data, the ammonium salt of nitrodiethylmalonate; catalytic reduction of this compound with hydrogen followed by treatment with the chloranhydride of the 2-nitroxyethyl ester of succinamic acid yielded 2-...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2015-06, Vol.49 (3), p.192-195
Main Authors: Fedorov, B. S., Fadeev, M. A., Golovina, N. I., Dorokhov, V. G., Shilov, G. V., Utenyshev, A. N.
Format: Article
Language:English
Subjects:
Drug Synthesis Methods and Manufacturing Technology
Hydrogen
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:Interaction of hydroxymethylnitrodiethylmalonate with ammonia produced, in contrast to published data, the ammonium salt of nitrodiethylmalonate; catalytic reduction of this compound with hydrogen followed by treatment with the chloranhydride of the 2-nitroxyethyl ester of succinamic acid yielded 2-nitroxyethylsuccinylaminodiethylmalonate. The final structures of the ammonium salt of nitrodiethylmalonate and 2-nitroxyethylsuccinylaminodiethylmalonate were identified by x-ray diffraction analysis.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-015-1252-6