New 3-[2′(R)-Hydroxybutyl]-7-Hydroxyphthalide from Marine Isolate of the Fungus Penicillium claviforme

The new phthalide derivative 3-[2′(R)-hydroxybutyl]-7-hydroxyphthalide (2) and the five known compounds (−)-3-butyl-7-hydroxyphthalide (1), isopatulin (3), m-hydroxybenzyl alcohol (4), cyclopenin (5), and cyclopeptine (6) were isolated from the marine isolate of the fungus Penicillium claviforme ass...

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Bibliographic Details
Published in:Chemistry of natural compounds 2015-01, Vol.51 (1), p.111-115
Main Authors: Afiyatullov, Sh. Sh, Leshchenko, E. V, Sobolevskaya, M. P, Gerasimenko, A. V, Khudyakova, Yu. V, Kirichuk, N. N, Mikhailov, V. V
Format: Article
Language:English
Subjects:
alcohols
chemistry
Fungi
mass spectrometry
Medicine
Nuclear magnetic resonance spectroscopy
Organic Chemistry
Penicillium
Pharmacy
Plant Sciences
seagrasses
Zostera marina
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Summary:The new phthalide derivative 3-[2′(R)-hydroxybutyl]-7-hydroxyphthalide (2) and the five known compounds (−)-3-butyl-7-hydroxyphthalide (1), isopatulin (3), m-hydroxybenzyl alcohol (4), cyclopenin (5), and cyclopeptine (6) were isolated from the marine isolate of the fungus Penicillium claviforme associated with the seagrass Zostera marina. The structures of the compounds were established using NMR spectroscopy and mass spectrometry. The absolute configuration of the C-2′ asymmetric center was determined using a modified Mosher method.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-015-1214-y