Synthesis of the first 13-nitroaryl derivatives of 8-acetonylberberine

For the first time a method for the synthesis of 8-acetonylberberine 13-nitroaryl derivatives has been developed comprising a one-pot reaction of berberine, acetone, and neutral aromatic electrophiles (picryl chloride, 4-chloro-7-nitrobenzofurazan, 4-chloro-5,7-dinitrobenzofurazan). It was found tha...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2015-08, Vol.51 (8), p.772-774
Main Authors: Burov, Oleg N., Kurbatov, Sergey V., Morozov, Pavel G., Kletskii, Mikhail E., Tatarov, Artem V.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
Pharmacy
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Summary:For the first time a method for the synthesis of 8-acetonylberberine 13-nitroaryl derivatives has been developed comprising a one-pot reaction of berberine, acetone, and neutral aromatic electrophiles (picryl chloride, 4-chloro-7-nitrobenzofurazan, 4-chloro-5,7-dinitrobenzofurazan). It was found that the reaction of 8-acetonylberberine with these chloronitroarenes does not lead to the formation of the target compounds.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-015-1774-6