Antinociceptive and sedative effects of buprenorphine, acepromazine, or combination of both, in conscious cats/Efeitos antinociceptivos e sedativos da buprenorfina, da acepromazina ou da associacao buprenorfina e acepromazina em gatos

• Published in: Ciência rural 2010-10, Vol.40 (10), p.2122
• Main Authors: Santana, Luciana Alvarez, Luna, Stelio Pacca Loureiro, Steagall, Paulo Vinicius Mortensen, Ferreira, Tatiana Henriques, Taylor, Polly, Dixon, Mike
• Format: Article
• Language: Spanish
• Subjects: Analysis; Buprenorphine; Cats
• ISSN: 0103-8478

The antinociceptive effects of buprenorphine have been reported in dogs and cats. This study evaluated changes in the mechanical nociceptive threshold and the sedative effects of buprenorphine, acepromazine and its combination in cats, determined by the same observer using a nociceptive threshold testing device and DIVAS, respectively. Eight animals were previously conditioned to the procedures. After four baseline measurements, 0.02mg [kg.sup.-1] of buprenorphine, 0.06mg.[kg.sup.-1] of acepromazine, or 0.01mg [kg.sup.-1] of buprenorphine with 0.03mg [kg.sup.-1] of acepromazine were administered intramuscularly in a blinded and experimental study using a Latin square design within a one week interval between treatments. The antinociceptive and sedative effects were evaluated at 15, 30, 45 minutes and 1, 2, 3, 4, 6, 8 and 12 hours post treatment. The nociceptive threshold increased significantly only after the combination buprenorphine-acepromazine (between 45 minutes and 1 hour). Regarding sedation, the use of acepromazine and the combination of both were associated with significantly higher DIVAS values from 15 minutes to 4 hours and 1 5 minutes to 3 hours post treatment, respectively. No increase in these values was noted with the use of buprenorphine. It was concluded that it could not be verified the superiority of neuroleptanalgesia over the use of drugs alone Key words: acepromazine, analgesia, antinociception, buprenorphine, cat, neuroleptanalgesia. O efeito antinociceptivo da buprenorfina tem sido relatado em caes e gatos. No presente estudo, avaliou-se o limiar nociceptivo mecanico em felinos tratados com buprenorfina, acepromazina ou ambas associadas e foram comparados os efeitos antinociceptivos e sedativos da associacao em relacao ao uso isolado desses farmacos determinados pelo mesmo observador, por meio de analgesiometro e da escala analogica visual dinamica interativa (DIVAS), respectivamente. Os oito animais empregados no estudo foram previamente familiarizados com os procedimentos utilizados. Apos quatro mensuracoes basais, foram administrados, por via intramuscular, 0,02mg [kg.sup.-1] de buprenorfina, 0,06mg [kg.sup.-1] de acepromazina ou 0,01mg kgde buprenorfina associada a 0,03mg [kg.sup.-1] de acepromazina, em um estudo cego, com delineamento em quadrado latino e tratamento semanal. Os efeitos antinociceptivos e sedativos foram avaliados aos 15, 30, 45 minutos e uma, duas, tres, quatro, seis, oito e 12 horas apos a administracao do tra