Higher Plasma Myostatin Levels in Cor Pulmonale Secondary to Chronic Obstructive Pulmonary Disease

Objective To analyze plasma myostatin levels and investigate their relationship with right ventricular (RV) function in patients with cor pulmonale secondary to chronic obstructive pulmonary disease (COPD). Methods The study recruited 81 patients with advanced COPD and 40 age-matched controls. The p...

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Published in:PLoS ONE 2016, Vol.11 (3)
Main Authors: Ju, Chun-rong, Chen, Miao, Zhang, Jian-heng, Lin, Zhi-ya, Chen, Rong-chang
Format: Report
Language:English
Subjects:
Analysis
Chronic obstructive lung disease
Complications and side effects
Cor pulmonale
Myostatin
Risk factors
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Chen, Miao
Zhang, Jian-heng
Lin, Zhi-ya
Chen, Rong-chang
description Objective To analyze plasma myostatin levels and investigate their relationship with right ventricular (RV) function in patients with cor pulmonale secondary to chronic obstructive pulmonary disease (COPD). Methods The study recruited 81 patients with advanced COPD and 40 age-matched controls. The patients were divided into two groups: those with cor pulmonale and those without. Echocardiography was used to evaluate RV function and morphology, and the value of tricuspid annular plane systolic excursion (TAPSE) less than 16 mm was considered RV dysfunction. Plasma myostatin levels were analyzed by enzyme-linked immunosorbent assay, and B-type natriuretic peptide (BNP) levels were analyzed as a comparison of myostatin. Results The data detected cor pulmonale in 39/81 patients, with the mean value of TAPSE of 14.3 mm. Plasma myostatin levels (ng/mL) were significantly higher in patients with cor pulmonale (16.68 ± 2.95) than in those without (13.56 ± 3.09), and much higher than in controls (8.79±2.79), with each p
doi_str_mv 10.1371/journal.pone.0150838
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Methods The study recruited 81 patients with advanced COPD and 40 age-matched controls. The patients were divided into two groups: those with cor pulmonale and those without. Echocardiography was used to evaluate RV function and morphology, and the value of tricuspid annular plane systolic excursion (TAPSE) less than 16 mm was considered RV dysfunction. Plasma myostatin levels were analyzed by enzyme-linked immunosorbent assay, and B-type natriuretic peptide (BNP) levels were analyzed as a comparison of myostatin. Results The data detected cor pulmonale in 39/81 patients, with the mean value of TAPSE of 14.3 mm. Plasma myostatin levels (ng/mL) were significantly higher in patients with cor pulmonale (16.68 ± 2.95) than in those without (13.56 ± 3.09), and much higher than in controls (8.79±2.79), with each p&lt;0.01. Significant differences were also found in plasma BNP levels among the three groups (p&lt;0.05). Multivariate regression analysis suggested that myostatin levels were significantly correlated with the values of TAPSE and RV myocardium performance index among the COPD patients, and that BNP levels were significantly correlated only with systolic pulmonary arterial pressure, with each p&lt;0.05. Conclusions Plasma myostatin levels are increased in COPD patients who have cor pulmonale. Stronger correlations of plasma myostatin levels with echocardiographic indexes of the right heart suggest that myostatin might be superior to BNP in the early diagnosis of cor pulmonale in COPD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0150838</identifier><language>eng</language><publisher>Public Library of Science</publisher><subject>Analysis ; Chronic obstructive lung disease ; Complications and side effects ; Cor pulmonale ; Myostatin ; Risk factors</subject><ispartof>PLoS ONE, 2016, Vol.11 (3)</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>776,780,4476,27902</link.rule.ids></links><search><creatorcontrib>Ju, Chun-rong</creatorcontrib><creatorcontrib>Chen, Miao</creatorcontrib><creatorcontrib>Zhang, Jian-heng</creatorcontrib><creatorcontrib>Lin, Zhi-ya</creatorcontrib><creatorcontrib>Chen, Rong-chang</creatorcontrib><title>Higher Plasma Myostatin Levels in Cor Pulmonale Secondary to Chronic Obstructive Pulmonary Disease</title><title>PLoS ONE</title><description>Objective To analyze plasma myostatin levels and investigate their relationship with right ventricular (RV) function in patients with cor pulmonale secondary to chronic obstructive pulmonary disease (COPD). Methods The study recruited 81 patients with advanced COPD and 40 age-matched controls. The patients were divided into two groups: those with cor pulmonale and those without. Echocardiography was used to evaluate RV function and morphology, and the value of tricuspid annular plane systolic excursion (TAPSE) less than 16 mm was considered RV dysfunction. Plasma myostatin levels were analyzed by enzyme-linked immunosorbent assay, and B-type natriuretic peptide (BNP) levels were analyzed as a comparison of myostatin. Results The data detected cor pulmonale in 39/81 patients, with the mean value of TAPSE of 14.3 mm. Plasma myostatin levels (ng/mL) were significantly higher in patients with cor pulmonale (16.68 ± 2.95) than in those without (13.56 ± 3.09), and much higher than in controls (8.79±2.79), with each p&lt;0.01. Significant differences were also found in plasma BNP levels among the three groups (p&lt;0.05). Multivariate regression analysis suggested that myostatin levels were significantly correlated with the values of TAPSE and RV myocardium performance index among the COPD patients, and that BNP levels were significantly correlated only with systolic pulmonary arterial pressure, with each p&lt;0.05. Conclusions Plasma myostatin levels are increased in COPD patients who have cor pulmonale. Stronger correlations of plasma myostatin levels with echocardiographic indexes of the right heart suggest that myostatin might be superior to BNP in the early diagnosis of cor pulmonale in COPD.</description><subject>Analysis</subject><subject>Chronic obstructive lung disease</subject><subject>Complications and side effects</subject><subject>Cor pulmonale</subject><subject>Myostatin</subject><subject>Risk factors</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>2016</creationdate><recordtype>report</recordtype><sourceid/><recordid>eNqVjc2KAjEQhMPiwvqzb7CHvIBjYpwfjzKueFAU9C5x7NFIJr2kM4JvvzkoeJU-dFFV_TVjP1IkUuVydMXWO22TP3SQCJmKQhUfrCunajzMxkJ1XvQX6xFdhUhVkWVddlya8wU831pNjebrO1LQwTi-ghtY4lGVGOPWNhhfAN9Bhe6k_Z0H5OXFozMV3xwp-LYK5gbPaizMDYEmGLDPWluC78fus2Txuy-Xw3PkHYyrMXhdxTlBYyIcahP92SRVk1zkU6XePvgHu69XWQ</recordid><startdate>20160321</startdate><enddate>20160321</enddate><creator>Ju, Chun-rong</creator><creator>Chen, Miao</creator><creator>Zhang, Jian-heng</creator><creator>Lin, Zhi-ya</creator><creator>Chen, Rong-chang</creator><general>Public Library of Science</general><scope/></search><sort><creationdate>20160321</creationdate><title>Higher Plasma Myostatin Levels in Cor Pulmonale Secondary to Chronic Obstructive Pulmonary Disease</title><author>Ju, Chun-rong ; Chen, Miao ; Zhang, Jian-heng ; Lin, Zhi-ya ; Chen, Rong-chang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-gale_infotracacademiconefile_A4534707933</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Analysis</topic><topic>Chronic obstructive lung disease</topic><topic>Complications and side effects</topic><topic>Cor pulmonale</topic><topic>Myostatin</topic><topic>Risk factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Ju, Chun-rong</creatorcontrib><creatorcontrib>Chen, Miao</creatorcontrib><creatorcontrib>Zhang, Jian-heng</creatorcontrib><creatorcontrib>Lin, Zhi-ya</creatorcontrib><creatorcontrib>Chen, Rong-chang</creatorcontrib></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ju, Chun-rong</au><au>Chen, Miao</au><au>Zhang, Jian-heng</au><au>Lin, Zhi-ya</au><au>Chen, Rong-chang</au><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><atitle>Higher Plasma Myostatin Levels in Cor Pulmonale Secondary to Chronic Obstructive Pulmonary Disease</atitle><jtitle>PLoS ONE</jtitle><date>2016-03-21</date><risdate>2016</risdate><volume>11</volume><issue>3</issue><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Objective To analyze plasma myostatin levels and investigate their relationship with right ventricular (RV) function in patients with cor pulmonale secondary to chronic obstructive pulmonary disease (COPD). Methods The study recruited 81 patients with advanced COPD and 40 age-matched controls. The patients were divided into two groups: those with cor pulmonale and those without. Echocardiography was used to evaluate RV function and morphology, and the value of tricuspid annular plane systolic excursion (TAPSE) less than 16 mm was considered RV dysfunction. Plasma myostatin levels were analyzed by enzyme-linked immunosorbent assay, and B-type natriuretic peptide (BNP) levels were analyzed as a comparison of myostatin. Results The data detected cor pulmonale in 39/81 patients, with the mean value of TAPSE of 14.3 mm. Plasma myostatin levels (ng/mL) were significantly higher in patients with cor pulmonale (16.68 ± 2.95) than in those without (13.56 ± 3.09), and much higher than in controls (8.79±2.79), with each p&lt;0.01. Significant differences were also found in plasma BNP levels among the three groups (p&lt;0.05). Multivariate regression analysis suggested that myostatin levels were significantly correlated with the values of TAPSE and RV myocardium performance index among the COPD patients, and that BNP levels were significantly correlated only with systolic pulmonary arterial pressure, with each p&lt;0.05. Conclusions Plasma myostatin levels are increased in COPD patients who have cor pulmonale. Stronger correlations of plasma myostatin levels with echocardiographic indexes of the right heart suggest that myostatin might be superior to BNP in the early diagnosis of cor pulmonale in COPD.</abstract><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0150838</doi></addata></record>
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subjects Analysis
Chronic obstructive lung disease
Complications and side effects
Cor pulmonale
Myostatin
Risk factors
title Higher Plasma Myostatin Levels in Cor Pulmonale Secondary to Chronic Obstructive Pulmonary Disease
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