Genomic insights into the origin of farming in the ancient Near East

• Published in: Nature 2016, Vol.536 (7617), p.419
• Main Authors: Lazaridis, Iosif, Nadel, Dani, Rollefson, Gary, Merrett, Deborah C, Rohland, Nadin, Mallick, Swapan, Fernandes, Daniel, Novak, Mario, Gamarra, Beatriz, Sirak, Kendra, Connell, Sarah, Stewardson, Kristin, Harney, Eadaoin, Fu, Qiaomei, Gonzalez-Fortes, Gloria, Jones, Eppie R, Roodenberg, Songl Alpaslan, Lengyel, Gyrgy, Bocquentin, Fanny, Gasparian, Boris, Monge, Janet M, Gregg, Michael, Eshed, Vered, Mizrahi, Ahuva-Sivan, Meiklejohn, Christopher, Gerritsen, Fokke, Bejenaru, Luminita, Blher, Matthias, Campbell, Archie, Cavalleri, Gianpiero, Comas, David, Froguel, Philippe, Gilbert, Edmund, Kerr, Shona M, Kovacs, Peter, Krause, Johannes, McGettigan, Darren, Merrigan, Michael, Merriwether, D. Andrew, OReilly, Seamus, Richards, Ma, Semino, Ornella, Shamoon-Pour, Michel, Stefanescu, Gheorghe, Stumvoll, Michael, Tnjes, Anke, Torroni, Antonio, Wilson, James F, Yengo, Loic, Hovhannisyan, Nelli A, Patterson, Nick, Pinhasi, Ron, Reich, David
• Format: Report
• Language: English
• Subjects: Agriculture; Genetic aspects; Genome-wide association studies; History
• ISSN: 0028-0836
• DOI: 10.1038/nature19310

We report genome-wide ancient DNA from 44 ancient Near Easterners ranging in time between 12,000 and 1,400 bc, from Natufian huntergatherers to Bronze Age farmers. We show that the earliest populations of the Near East derived around half their ancestry from a Basal Eurasian lineage that had little if any Neanderthal admixture and that separated from other non-African lineages before their separation from each other. The first farmers of the southern Levant (Israel and Jordan) and Zagros Mountains (Iran) were strongly genetically differentiated, and each descended from local huntergatherers. By the time of the Bronze Age, these two populations and Anatolian-related farmers had mixed with each other and with the huntergatherers of Europe to greatly reduce genetic differentiation. The impact of the Near Eastern farmers extended beyond the Near East: farmers related to those of Anatolia spread westward into Europe; farmers related to those of the Levant spread southward into East Africa; farmers related to those of Iran spread northward into the Eurasian steppe; and people related to both the early farmers of Iran and to the pastoralists of the Eurasian steppe spread eastward into South Asia.