Synthesis, Antimicrobial and In Silico EGFR Inhibitory Activity Evaluation of Sulfonylamino Pyrrolidine Derivatives

A series of novel sulfonylamino pyrrolidine derivatives were synthesized, characterized and evaluated for their antimicrobial activity. All compounds exhibited moderate activity against the microorganisms tested. The compounds were evaluated in silico for their ability to inhibit epidermal growth fa...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2016-10, Vol.50 (7), p.443-450
Main Authors: Kumar, B. Santosh, Prasad, A. Raghavendra Guru, Reddy, P. Raveendra, Ravindranath, L. K.
Format: Article
Language:English
Subjects:
Alkaloids
Analysis
Chemical properties
Epidermal growth factors
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:A series of novel sulfonylamino pyrrolidine derivatives were synthesized, characterized and evaluated for their antimicrobial activity. All compounds exhibited moderate activity against the microorganisms tested. The compounds were evaluated in silico for their ability to inhibit epidermal growth factor receptor (EGFR). Docking in silico demonstrated that the sulfonylamino pyrrolidine derivatives represent a new class of EGFR inhibitors and bind at the ATP binding pocket of the tyrosine kinase domain of EGFR. The free energy of binding and inhibition constant ( k i ) of the docked compounds were evaluated.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-016-1467-1