Preparation of Biologically Active Film-Forming Materials Based on Polyphosphate-Modified Chitosan

The processes of preparing film-forming materials based on chitosan with surface modification and ionic cross-linking using sodium tripolyphosphate and potassium pyrophosphate respectively were studied. Optimum cross-linking conditions were identified by studying the interactions of chitosan with di...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2016-08, Vol.50 (4), p.250-257
Main Authors: Kasatkina, M. A., Budantseva, N. A., Kil’deeva, N. R.
Format: Article
Language:English
Subjects:
Drug Synthesis Methods and Manufacturing Technology
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Sodium tripolyphosphate
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Summary:The processes of preparing film-forming materials based on chitosan with surface modification and ionic cross-linking using sodium tripolyphosphate and potassium pyrophosphate respectively were studied. Optimum cross-linking conditions were identified by studying the interactions of chitosan with different levels of amino group protonation with polyphosphates with different numbers of ionized groups. These studies showed that changes in the duration of treatment of films allowed the level of swelling to be varied over the range 165% to 148% for potassium pyrophosphate and from 196% to 80% for sodium tripolyphosphate. Studies of the kinetics of study drug release showed that changes in the conditions used for modification with polyphosphates could increase the duration of release of the biologically active components to 8 h.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-016-1432-z