Central Sleep Apnoea Is Related to the Severity and Short-Term Prognosis of Acute Coronary Syndrome

• Published in: PLoS ONE 2016, Vol.11 (11), p.e0167031
• Main Authors: Florés, Marina, de Batlle, Jordi, Sánchez-de-la-Torre, Alicia, Sánchez-de-la-Torre, Manuel, Aldomá, Albina, Worner, Fernando, Galera, Estefanía, Seminario, Asunción, Torres, Gerard, Dalmases, Mireia, Montserrat, Josep M, Garmendia, Onintza, Barbé, Ferran
• Format: Report
• Language: English
• Subjects: Acute coronary syndrome; Complications and side effects; Diagnosis; Prognosis; Risk factors; Sleep apnea
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0167031

Objective To evaluate the relation of central sleep apnoea (CSA) to the severity and short-term prognosis of patients who experience acute coronary syndrome (ACS). Methods Observational study with cross-sectional and longitudinal analyses. Patients acutely admitted to participating hospitals because of ACS underwent respiratory polygraphy during the first 24 to 72 h. CSA was defined as an apnoea-hypopnoea index (AHI) >15 events*h.sup.-1 (>50% of central apnoeas). ACS severity (Killip class, ejection fraction, number of diseased vessels and peak plasma troponin) was evaluated at baseline, and short-term prognosis (length of hospitalization, complications and mortality) was evaluated at discharge. Results A total of 68 CSA patients (AHI 31±18 events*h.sup.-1, 64±12 years, 87% males) and 92 controls (AHI 7±5 events*h.sup.-1, 62±12 years, 84% males) were included in the analyses. After adjusting for age, body mass index, hypertension and smoking status, patients diagnosed with CSA spent more days in the coronary unit compared with controls (3.7±2.9 vs. 1.5±1.7; p