Microencapsulation of Imatinib Methanesulfonate

(Protamine—pectin) 4 and (protamine—pectin)8 microcapsules and those containing also Ag nanoparticles were formed using the polyelectrolyte layer-by-layer (LbL) self-assembly method. The efficiency of imatinib methanesulfonate encapsulation in the microcapsules was 85.0 ± 6.0%. Microcapsules contain...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2017-09, Vol.51 (6), p.486-490
Main Authors: Gilevskaya, K. S., Ignatovich, Zh. V., Golubeva, M. B., Koroleva, E. V., Agabekov, V. E.
Format: Article
Language:English
Subjects:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Polyelectrolytes
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Summary:(Protamine—pectin) 4 and (protamine—pectin)8 microcapsules and those containing also Ag nanoparticles were formed using the polyelectrolyte layer-by-layer (LbL) self-assembly method. The efficiency of imatinib methanesulfonate encapsulation in the microcapsules was 85.0 ± 6.0%. Microcapsules containing up to 50 mass% imatinib methanesulfonate and providing a prolonged release profile of the encapsulated drug were prepared. Encapsulation of imatinib in microcapsules increased its cytostatic activity (IC 50 values reduced by 1.2 – 3.5 times) as compared with the free drug on the Molt-4, K-562, and KG-1 cell lines.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-017-1639-7