Osseointegration of Hydroxyapatite Implants in Rat Tibial Defects with Sciatic Nerve Injury/Oseointegracion de Implantes de Hidroxiapatita en Defectos Tibiales de Ratas con Lesion del Nervio Ciatico

Bone metabolism is influenced by different factors and muscle activity acts as a stimulator of bone plasticity. Conditions such as nerve injuries can compromise bone physiology due to muscle inactivity. Preview studies have shown that nerve damage reduces P substance and calcitonin gene-related pept...

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Bibliographic Details
Published in:International journal of morphology 2015-06, Vol.33 (2), p.620
Main Authors: da Cunha, Marcelo Rodrigues, Laraia, Isabela O, Franco, Guacira R, Miguel, Natalia N, Maciel, Ana A, dos Santos, Geovane Ribeiro, Isayama, Ricardo Noboro
Format: Article
Language:Spanish
Subjects:
Hydroxyapatites
Paralysis
Physiological aspects
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Summary:Bone metabolism is influenced by different factors and muscle activity acts as a stimulator of bone plasticity. Conditions such as nerve injuries can compromise bone physiology due to muscle inactivity. Preview studies have shown that nerve damage reduces P substance and calcitonin gene-related peptides, also known as neuropeptides that may have a key role on bone healing. Therefore, this study evaluated the osseointegration of hydroxyapatite implants in tibial defects of rats submitted to unilateral sciatic nerve section. Twelve Wistar rats were divided into two groups (G1 and G2). In G1, the sciatic nerve was left intact and in G2 the left sciatic nerve was completely sectioned. An experimental tibial bone defect was then created in both groups and filled with hydroxyapatite granules. The animals were sacrificed 2 months after implantation and samples were submitted to macroscopic inspection and histological analysis. Good radiopacity of the hydroxyapatite granules and radiographic definition of the bone defect were noted. Histologic analysis revealed formation of new bone adjacent to the hydroxyapatite granules in G1 and, to a lesser extent, in G2 in which the proliferation of connective tissue predominated at the implant site. The formation of new bone stimulated by hydroxyapatite in bone defects can be expected even in animals with limb paralysis due to nerve injury; however, bone formation occurs at a slower speed in these animals and the volume of newly formed bone is lower. KEY WORDS: Hydroxyapatite; Sciatic nerve; Bone healing. El metabolismo oseo esta influenciado por diferentes factores y la actividad muscular como un estimulador de la plasticidad osea. Condiciones tales como lesiones nerviosas pueden comprometer la fisiologia osea debido a la inactividad muscular. Estudios previos han demostrado que el dano nervioso reduce la sustancia P y el peptido relacionado con el gen de la calcitonina, tambien conocidos como neuropeptidos que pueden tener un papel clave en la cicatrizacion osea. Este estudio evaluo la oseointegracion de los implantes de hidroxiapatita en defectos tibiales de ratas sometidas a la seccion del nervio ciatico unilateralmente. Doce ratas Wistar se dividieron en dos grupos (G1 y G2). En G1, el nervio ciatico se dejo intacto y en el G2 el nervio ciatico izquierdo fue completamente seccionado. Un defecto oseo tibial fue creado experimentalmente en ambos grupos y se relleno con granulos de hidroxiapatita. Los animales se sacrifica
ISSN:0717-9367