Effects of Xylene on Respiratory Mucosa in Rats/ Efectos del Xileno sobre la Mucosa Respiratoria de Ratas

In this study we examined the effects histopathologic and immunohistochemical of xylene inhalation in rats by using light microscopy. Adult wistar albino rats were used in this study. Eight rats were in control group and 8 rats were in the experimental group. The experimental group was exposed to 30...

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Bibliographic Details
Published in:International journal of morphology 2016-09, Vol.34 (3), p.934
Main Authors: Eda, Arslan, Baver, Samanci, Seyla, Samanci Bolukbasi, Huseyin, Ozevren, Deveci, E
Format: Article
Language:Spanish
Subjects:
Endothelium
Formaldehyde
Vascular endothelial growth factor
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Summary:In this study we examined the effects histopathologic and immunohistochemical of xylene inhalation in rats by using light microscopy. Adult wistar albino rats were used in this study. Eight rats were in control group and 8 rats were in the experimental group. The experimental group was exposed to 300 ppm formaldehyde 3-5 min/day, 5 days/week for 8 weeks. The lining epithelium of respiratory mucosa showed a loss of ciliated cells with metaplasia of goblet cells, hyperplasia of squamous cells and edema, inflamation in sub epithelial area). In the group treated xylene. Disruption of cell-cell contact was observed. Weak expression of E-cadherin was observed between cells. The vascular endothelium of capillaries and venoles showed intense immunostaining for VEGF. KEY WORDS: Xylene; Vascular endothelial growth factor; E-Cadherin; Respiratory mucosa. Se examino el efecto histopatologico e inmunohistoquimico de la inhalacion de xileno en ratas mediante el uso de microscopia de luz. Se utilizaron ratas albinas Wistar adultas. Ocho ratas formaron parte del grupo control y 8 del grupo experimental. El grupo experimental fue expuesto a 300 ppm de formaldehido, 3-5 min/dia, 5 dias/semana, durante 8 semanas. El epitelio de revestimiento de la mucosa respiratoria mostro una perdida de celulas ciliadas con metaplasia de celulas caliciformes, hiperplasia de celulas escamosas y edema, con inflamacion en la zona subepitelial. En el grupo tratado con xileno se observo una interrupcion del contacto celula-celula. Se observo una debil expresion de E-cadherina entre las celulas. El endotelio vascular de los capilares y venulas mostraron intensa inmunotincion de VEGF. PALABRAS CLAVE: Xileno; Factor de crecimiento vascular endotelial; E-cadherina; Mucosa respiratoria.
ISSN:0717-9367