Expression of merlin, NDRG2, ERBB2, and c-MYC in meningiomas: relationship with tumor grade and recurrence

Meningiomas are common, usually benign tumors of the central nervous system that have a high rate of post-surgical recurrence or regrowth. We determined expression of the proteins merlin, NDRG2, ERBB2, and c-MYC in meningiomas using immunohistochemistry and assessed relationships between protein exp...

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Bibliographic Details
Published in:Brazilian Journal of Medical and Biological Research 2016, Vol.49 (4)
Main Authors: Ongaratti, B.R, Silva, C.B.O, Trott, G, Haag, T, Leaes, C.G.S, Ferreira, N.P, Oliveira, M.C, Pereira-Lima, J.F.S
Format: Report
Language:English
Subjects:
Gene expression
Genetic aspects
Meningioma
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Summary:Meningiomas are common, usually benign tumors of the central nervous system that have a high rate of post-surgical recurrence or regrowth. We determined expression of the proteins merlin, NDRG2, ERBB2, and c-MYC in meningiomas using immunohistochemistry and assessed relationships between protein expression and gender, age, tumor grade, and recurrence or regrowth. The study sample comprised 60 patients, (44 women and 16 men) with a mean age of 53.2 [+ or -] 12.7 years. Tumors were classified as grade I (n=48) or grades II and III (n=12). Expression of merlin, NDRG2, ERBB2, and c-MYC was not significantly different statistically with relation to gender, age, or meningioma recurrence or regrowth. Merlin was expressed in 100% of the cases. No statistically significant difference between tumor grade and recurrence or regrowth was identified. Statistically significant differences were identified between the mean age of patients with grade I (54.83 [+ or -] 11.60) and grades II and III (46.58 [+ or -] 15.08) meningiomas (P=0.043), between strong c-MYC expression and grades II and III (P
ISSN:0100-879X
DOI:10.1590/1414-431X20155125