Analgesic Rectal Suppositories Containing a Nonsteroidal Anti-Inflammatory Drug in Combination with a Tricyclic Antidepressant and Transmucosal Conductor

A composition and preparation method for new analgesic rectal suppositories containing a nonsteroidal anti-inflammatory drug (ketorolac), tricyclic antidepressant (amitriptyline), and transmucosal conductor (silicon glycerolates) as the active ingredients in a poly(ethylene glycol) (PEG-4000) base w...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2018-12, Vol.52 (9), p.786-789
Main Authors: Zyryanova, I. G., Larionov, L. P., Shadrina, E. V., Ivanenko, M. V., Khonina, T. G.
Format: Article
Language:English
Subjects:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:A composition and preparation method for new analgesic rectal suppositories containing a nonsteroidal anti-inflammatory drug (ketorolac), tricyclic antidepressant (amitriptyline), and transmucosal conductor (silicon glycerolates) as the active ingredients in a poly(ethylene glycol) (PEG-4000) base were proposed. The acute toxicity was determined and showed they were safe to use. The high analgesic activity of the suppositories was confirmed using electrical stimulation. Their high transmucosal activity in vitro was revealed by measuring the degree of diffusion of one of the active ingredients (amitriptyline) through a natural biological membrane. The results indicated that the developed suppositories could be recommended for further investigations of future medical use to relieve pain of various etiologies.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-018-1900-8