Synthesis and Anticonvulsant Activity of N-Substituted 4-Amino-3-Nitrocoumarins

The synthesis and anticonvulsant activity of new coumarin derivatives are reported. N -(3-Nitrocoumarin-4-yl)-4-aminobutyric acid ( 1a ) at doses of 60 and 80 mg/kg (in the MES test) and methyl N -(3,6-dinitrocoumarin-4-yl)-4-aminobutyrate ( 1e ) at doses of 20 and 40 mg/kg (in the corazole antagoni...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2019-05, Vol.53 (2), p.118-124
Main Authors: Mokrov, G. V., Savel’ev, V. L., Voronina, T. A., Litvinova, S. A., Kovalev, I. G., Nerobkova, L. N., Dmitrienko, A. O., Gudasheva, T. A., Seredenin, S. B.
Format: Article
Language:English
Subjects:
Amino acids
Anticonvulsants
Epilepsy
Medicine
Organic Chemistry
Pharmacology
Pharmacology/Toxicology
Pharmacy
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Summary:The synthesis and anticonvulsant activity of new coumarin derivatives are reported. N -(3-Nitrocoumarin-4-yl)-4-aminobutyric acid ( 1a ) at doses of 60 and 80 mg/kg (in the MES test) and methyl N -(3,6-dinitrocoumarin-4-yl)-4-aminobutyrate ( 1e ) at doses of 20 and 40 mg/kg (in the corazole antagonism test) possessed the greatest anticonvulsant activity of the synthesized compounds. The results indicated that the coumarin derivatives were promising for further development as potential anticonvulsant agents.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-019-01964-7