Inhibition of [alpha]-Amylase and [alpha]-Glucosidase by New [beta]-Aminopropionamidoxime Derivatives

New antidiabetic agents are being sought because of the global problem with diabetes. Amidoxime derivatives are known to have antidiabetic activity. [beta]-Aminopropionamidoxime bases and pharmacologically acceptable salts of O-aroyl-[beta]-(morpholin-1-yl)propionamidoximes and 5-substituted phenyl-...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2019-05, Vol.53 (2), p.129
Main Authors: Kayukova, L. A, Uzakova, A. B, Baitursynova, G. P, Dyusembaeva, G. T, Shul'gau, Z. T, Gulyaev, A. E, Sergazy, Sh. D
Format: Article
Language:English
Subjects:
Amylases
Hydrolases
Hypoglycemic agents
Real estate appraisal
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Summary:New antidiabetic agents are being sought because of the global problem with diabetes. Amidoxime derivatives are known to have antidiabetic activity. [beta]-Aminopropionamidoxime bases and pharmacologically acceptable salts of O-aroyl-[beta]-(morpholin-1-yl)propionamidoximes and 5-substituted phenyl-3-[beta]-(piperidin-1-yl and morpholin-1-yl)ethyl-1,2,4-oxadiazoles were screened in vitro for antidiabetic activity manifested as inhibition of [alpha]-amylase and [alpha]-glucosidase. Compounds with pronounced antidiabetic properties were identified. The series of 3,5-disubstituted 1,2,4-oxadiazoles were more active than the series of O-aroyl-[beta]-aminopropionamidoximes. The results could be used for further in vivo screening of the antidiabetic properties of the most promising compounds with a preliminary assessment of their mean toxic doses in animals.
ISSN:0091-150X
DOI:10.1007/s11094-019-01966-5