Overweight and obesity as predictors of early mortality in Mexican children with acute lymphoblastic leuzkemia: a multicenter cohort study

• Published in: BMC Cancer 2019, Vol.19 (1)
• Main Authors: Núéez-Enríquez, Juan Carlos, Gil-Hernández, Ana Elena, Jiménez-Hernández, Elva, Fajardo-Gutiérrez, Arturo, Medina-Sansón, Aurora, Flores-Lujano, Janet, Espinoza-Hernández, Laura Eugenia, Duarte-Rodríguez, David Aldebarán, Amador-Sánchez, Raquel, Peéaloza-González, José Gabriel, Torres-Nava, José Refugio, Espinosa-Elizondo, Rosa Martha, Flores-Villegas, Luz Victoria, Merino-Pasaye, Laura Elizabeth, Pérez-Saldivar, María Luisa, Dorantes-Acosta, Elisa María, Cortés-Herrera, Beatriz, Solis-Labastida, Karina Anastacia, Núéez-Villegas, Nora Nancy, Velázquez-Aviéa, Martha Margarita, Rangel-López, Angélica, González-Ãvila, Ana Itamar, Santillán-Juárez, Jessica Denisse, García-Velázquez, Alejandra Jimena, Jiménez-Morales, Silvia, Bekker-Méndez, Vilma Carolina, Rosas-Vargas, Haydee, Mata-Rocha, Minerva, Sepúlveda-Robles, Omar Alejandro, Martín-Trejo, Jorge Alfonso, Mejía-Aranguré, Juan Manuel
• Format: Report
• Language: English
• Subjects: Acute lymphocytic leukemia; Analysis; Cancer research; Child health; Childhood obesity; Cohort analysis; Control; Diagnosis; Epidemics; Lymphocytic leukemia; Mexico; Mortality; Obesity; Patient outcomes; Public health; World health
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-019-5878-8

Background Mexico City has one of the highest incidences and mortality rates of acute lymphoblastic leukemia (ALL) in the world and a high frequency of early relapses (17%) and early mortality (15%). Otherwise, childhood overweight and obesity are reaching epidemic proportions. They have been associated with poor outcomes in children with ALL. The aim of present study was to identify if overweight and obesity are predictors of early mortality and relapse in Mexican children with ALL. Methods A multicenter cohort study was conducted. ALL children younger than 15 years old were included and followed-up during the first 24 months after diagnosis. Overweight and obesity were classified according World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) criteria. Early mortality and early relapses were the main outcomes. Results A total of 1070 children were analyzed. Overweight/obesity at diagnosis were predictors of early mortality (WHO: HR = 1.4, 95%CI:1.0-2.0; CDC: HR = 1.6, 95%CI:1.1-2.3). However, no associations between overweight (WHO: HR = 1.5, 95%CI:0.9-2.5; CDC: HR = 1.0; 95% CI:0.6-1.6) and obesity (WHO: HR = 1.5, 95%CI:0.7-3.2; CDC: HR = 1.4; 95%CI:0.9-2.3) with early relapse were observed. Conclusions Overweight and obese patients embody a subgroup with high risk of dying during leukemia treatment. Keywords: Children, Leukemia, Overweight, Obesity, Early mortality, Mexico