Systemic expression of Alu RNA in patients with geographic atrophy secondary to age-related macular degeneration

Geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is characterized by irreversible loss of macular retinal tissue and retinal pigment epithelium (RPE) cells. Several studies have revealed that accumulation of Alu RNA in RPE cell causes RPE cell degeneration in AMD. In the p...

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Bibliographic Details
Published in:PLoS ONE 2019, Vol.14 (8), p.e0220887
Main Authors: Yoshida, Hiroyuki, Matsushita, Tokiyoshi, Kimura, Erika, Fujita, Yukie, Keany, Robert, Ikeda, Toshihiro, Toshimori, Masanao, Imanaka, Takahiro, Nakamura, Masatsugu
Format: Report
Language:English
Subjects:
Development and progression
Epithelium
Gene expression
Genetic aspects
Health aspects
Macular degeneration
Risk factors
RNA
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Summary:Geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is characterized by irreversible loss of macular retinal tissue and retinal pigment epithelium (RPE) cells. Several studies have revealed that accumulation of Alu RNA in RPE cell causes RPE cell degeneration in AMD. In the present study, systemic Alu RNA expression levels were determined in 33 subjects with GA and 40 control subjects using a proprietary Alu RNA quantification method. It was observed that the expression level of Alu RNA was not significantly different between GA and Control groups (median = 21.3 in both GA and Control groups, P = 0.251). In addition, the systemic level of Alu RNA was not associated with subject characteristics, such as GA lesion size and SNP profiles of complement factors associated with increased risk of AMD. In conclusion, the usability of systemic Alu RNA expression level as a biomarker of GA secondary to AMD could not be established in this study.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0220887