Prevalence of extended-spectrum beta-lactamase producing bacteria from animal origin: A systematic review and meta-analysis report from India

• Published in: PLoS ONE 2019, Vol.14 (9), p.e0221771
• Main Authors: Kuralayanapalya, Suresh P, Patil, Sharanagouda S, Hamsapriya, Sudhakar, Shinduja, Rajamani, Roy, Parimal, Amachawadi, Raghavendra G
• Format: Report
• Language: English
• Subjects: Bacteria; Bacterial infections; Beef cattle; Beta lactamases; Drug resistance; Escherichia coli; Microbial drug resistance; Open source software; Pneumonia; Public health
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0221771

Antimicrobial resistance (AMR) due to the emergence and spread of extended-spectrum beta-lactamase (ESBL) producing bacteria are becoming a serious global public health concern. This article aims to assess the overall prevalence of ESBLs among animals in India, with year-wise, zone-wise and species-wise stratification. Systematic search from PubMed, Google Scholar and J-Gate Plus was carried out and 24 eligible articles from 2013-2019 in India were retrieved. The R Open source Scripting software was used to perform statistical analysis. The overall prevalence of ESBLs among animals in India was 9%. The pooled prevalence of ESBLs in animals were 26, 11, 6 and 8% for north, east, south and central zones, respectively. The reported prevalence of ESBLs in animals were 12, 5, 8, 8, 12, 13 and 33% were reported for the years 2013, 2014, 2015, 2016, 2017, 2018, 2019 respectively. The species-wise stratified results showed a predominance of ESBL producing Klebsiella pneumoniae strains (11%) when compared to Escherichia coli and Pseudomonas spp. which were 7% and 5%, respectively. The prevalence data generated could be utilized in infection control and in antibiotic use management decisions for developing appropriate intervention strategies.