A comprehensive database for integrated analysis of omics data in autoimmune diseases

Background Autoimmune diseases are heterogeneous pathologies with difficult diagnosis and few therapeutic options. In the last decade, several omics studies have provided significant insights into the molecular mechanisms of these diseases. Nevertheless, data from different cohorts and pathologies a...

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Bibliographic Details
Published in:BMC Bioinformatics 2021, Vol.22 (1)
Main Authors: Martorell-Marugán, Jordi, López-Domínguez, Raúl, García-Moreno, Adrián, Toro-Domínguez, Daniel, Villatoro-García, Juan Antonio, Barturen, Guillermo, Martín-Gómez, Adoración, Troule, Kevin, Gómez-López, Gonzalo, Al-Shahrour, Fátima, González-Rumayor, Víctor, Peéa-Chilet, María, Dopazo, Joaquín, Sáez-Rodríguez, Julio, Alarcón-Riquelme, Marta E, Carmona-Sáez, Pedro
Format: Report
Language:English
Subjects:
Analysis
Autoimmune diseases
Diagnosis
Genetic aspects
Genomics
Health aspects
Molecular diagnostic techniques
Risk factors
Online Access:Get full text
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Summary:Background Autoimmune diseases are heterogeneous pathologies with difficult diagnosis and few therapeutic options. In the last decade, several omics studies have provided significant insights into the molecular mechanisms of these diseases. Nevertheless, data from different cohorts and pathologies are stored independently in public repositories and a unified resource is imperative to assist researchers in this field. Results Here, we present Autoimmune Diseases Explorer ( Conclusions This is the first omics database focused on autoimmune diseases. This resource incorporates homogeneously processed data to facilitate integrative analyses among studies. Keywords: Autoimmune disease, Database, GEO, Transcriptomics, Epigenomics, Curation, Dataset, Interferon signature, Gene expression, Meta-analysis
ISSN:1471-2105
1471-2105
DOI:10.1186/s12859-021-04268-4