A comprehensive database for integrated analysis of omics data in autoimmune diseases

Background Autoimmune diseases are heterogeneous pathologies with difficult diagnosis and few therapeutic options. In the last decade, several omics studies have provided significant insights into the molecular mechanisms of these diseases. Nevertheless, data from different cohorts and pathologies a...

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Published in:BMC Bioinformatics 2021, Vol.22 (1)
Main Authors: Martorell-Marugán, Jordi, López-Domínguez, Raúl, García-Moreno, Adrián, Toro-Domínguez, Daniel, Villatoro-García, Juan Antonio, Barturen, Guillermo, Martín-Gómez, Adoración, Troule, Kevin, Gómez-López, Gonzalo, Al-Shahrour, Fátima, González-Rumayor, Víctor, Peéa-Chilet, María, Dopazo, Joaquín, Sáez-Rodríguez, Julio, Alarcón-Riquelme, Marta E, Carmona-Sáez, Pedro
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Language:English
Subjects:
Analysis
Autoimmune diseases
Diagnosis
Genetic aspects
Genomics
Health aspects
Molecular diagnostic techniques
Risk factors
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container_title BMC Bioinformatics
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creator Martorell-Marugán, Jordi
López-Domínguez, Raúl
García-Moreno, Adrián
Toro-Domínguez, Daniel
Villatoro-García, Juan Antonio
Barturen, Guillermo
Martín-Gómez, Adoración
Troule, Kevin
Gómez-López, Gonzalo
Al-Shahrour, Fátima
González-Rumayor, Víctor
Peéa-Chilet, María
Dopazo, Joaquín
Sáez-Rodríguez, Julio
Alarcón-Riquelme, Marta E
Carmona-Sáez, Pedro
description Background Autoimmune diseases are heterogeneous pathologies with difficult diagnosis and few therapeutic options. In the last decade, several omics studies have provided significant insights into the molecular mechanisms of these diseases. Nevertheless, data from different cohorts and pathologies are stored independently in public repositories and a unified resource is imperative to assist researchers in this field. Results Here, we present Autoimmune Diseases Explorer ( Conclusions This is the first omics database focused on autoimmune diseases. This resource incorporates homogeneously processed data to facilitate integrative analyses among studies. Keywords: Autoimmune disease, Database, GEO, Transcriptomics, Epigenomics, Curation, Dataset, Interferon signature, Gene expression, Meta-analysis
doi_str_mv 10.1186/s12859-021-04268-4
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In the last decade, several omics studies have provided significant insights into the molecular mechanisms of these diseases. Nevertheless, data from different cohorts and pathologies are stored independently in public repositories and a unified resource is imperative to assist researchers in this field. Results Here, we present Autoimmune Diseases Explorer ( Conclusions This is the first omics database focused on autoimmune diseases. This resource incorporates homogeneously processed data to facilitate integrative analyses among studies. 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In the last decade, several omics studies have provided significant insights into the molecular mechanisms of these diseases. Nevertheless, data from different cohorts and pathologies are stored independently in public repositories and a unified resource is imperative to assist researchers in this field. Results Here, we present Autoimmune Diseases Explorer ( Conclusions This is the first omics database focused on autoimmune diseases. This resource incorporates homogeneously processed data to facilitate integrative analyses among studies. 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source Publicly Available Content Database; PubMed Central
subjects Analysis
Autoimmune diseases
Diagnosis
Genetic aspects
Genomics
Health aspects
Molecular diagnostic techniques
Risk factors
title A comprehensive database for integrated analysis of omics data in autoimmune diseases
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