Molecular Biomarkers Associated with Early-Onset Symptomatic Intracranial Atherosclerosis

Purpose: Previous studies have shown a rising incidence of early-onset symptomatic intracranial atherosclerosis (sICAS), which has brought a severe economic burden to social development. This study aimed to evaluate the molecular biomarkers associated with early-onset sICAS and to seek possible inte...

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Bibliographic Details
Published in:Clinical Interventions in Aging 2021, Vol.16, p.1013
Main Authors: Luo, Yunfang, Yu, Fang, Feng, Xianjing, Liao, Di, Ying, Yuanlin, Li, Xi, Huang, Qin, Liu, Zeyu, Wei, Minping, Zhao, Tingting, Zhang, Lin, Tu, Ruxin, Xia, Jian
Format: Report
Language:English
Subjects:
Atherosclerosis
Biological markers
Cerebrovascular disease
Development and progression
Diagnosis
Genetic aspects
Health aspects
Identification and classification
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Summary:Purpose: Previous studies have shown a rising incidence of early-onset symptomatic intracranial atherosclerosis (sICAS), which has brought a severe economic burden to social development. This study aimed to evaluate the molecular biomarkers associated with early-onset sICAS and to seek possible intervention strategies for early prevention. Patients and Methods: We consecutively recruited patients with sICAS and divided them into two groups based on age: early-onset sICAS group as age [less than or equal to]60 years old and late-onset sICAS group as age >60 years old. We collected and compared the demographic data and laboratory results of each group. A bivariate logistic regression model was applied to evaluate the independent molecular biomarkers of early-onset sICAS. Results: A total of 1007 subjects with sICAS were enrolled in this study, comprising 519 patients in the early-onset sICAS group and 488 patients in the late-onset sICAS group. Bivariate logistic regression analysis demonstrated an increased level of white blood cell, platelet, albumin globulin ratio, free triiodothyronine, and a decreased level of total bile acid, urea nitrogen, high-density lipoprotein, homocysteine, and fibrinogen in the early-onset sICAS group when compared to the late-onset group. Conclusion: Our study showed the relevance between early sICAS and circulating levels of different molecular biomarkers. Detection of these related molecular biomarkers may provide a simple way for early sICAS preventions in the future. Keywords: ischemic stroke, symptomatic intracranial atherosclerosis, molecular biomarkers
ISSN:1178-1998
DOI:10.2147/CIA.S309945