Peculiarities of the Application of Mathematical Models Describing Mass-Transfer Processes in Film Coating Technology for a Biconvex Tablet

A review concerning peculiarities of the application of mathematical models describing mass-transfer processes in film coating technology is presented. A formula to calculate the coating film thickness for a biconvex tablet is given. A model based on the Fokker–Planck equation is described. It deter...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2022-07, Vol.56 (4), p.503-508
Main Authors: Tishkov, S. V., Gavrilov, D. I., Blynskaya, E. V., Alekseev, K. V., Bueva, V. V., Vinogradov, V. P.
Format: Article
Language:English
Subjects:
Coatings
Mathematical models
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:A review concerning peculiarities of the application of mathematical models describing mass-transfer processes in film coating technology is presented. A formula to calculate the coating film thickness for a biconvex tablet is given. A model based on the Fokker–Planck equation is described. It determines the law of distribution of coated tablets by weight and allows equations for calculating the average weight and dispersion of a coated tablet to be obtained. Therefore, the uniformity of the distribution of the coating material over the tablets can be evaluated. The mass-transfer equations shown in the review make it possible to calculate characteristics such as the product moisture content and the humidity in a coater drum.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-022-02668-1