A Simple "Green" Synthesis of Novel Bis-3-aryl-1,8-naphthyridines under Microwave Irradiation and Conventional Conditions

An eco-friendly and highly efficient synthesis of substituted bis(3-aryl-1,8-naphthyridin-2-yl)-sulfanes and 2-(methylthio)-3-aryl-1,8-naphthyridines under microwave and conventional conditions. The products are obtained with high yields and purity within short reaction time. The synthesized derivat...

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Bibliographic Details
Published in:Russian journal of general chemistry 2018-06, Vol.88 (6), p.1232
Main Authors: Ravi, D, Ashok, K, Rambabu, S, Sakram, B, Shyam, P
Format: Article
Language:English
Subjects:
Heterocyclic compounds
Sulfur compounds
Online Access:Get full text
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Summary:An eco-friendly and highly efficient synthesis of substituted bis(3-aryl-1,8-naphthyridin-2-yl)-sulfanes and 2-(methylthio)-3-aryl-1,8-naphthyridines under microwave and conventional conditions. The products are obtained with high yields and purity within short reaction time. The synthesized derivatives are screened for anti-microbial activity against bacteria and fungi. Molecular docking of the synthesized compounds with DNA Gyrase is studied. Keywords: 1,8-naphthyridines, anti-microbial activity, methanol, microwave Irradiation, molecular docking DOI: 10.1134/S1070363218060312
ISSN:1070-3632
DOI:10.1134/S1070363218060312