Urinary Excretion Kinetics of 9-(2-Diethylaminoethyl)-2-Phenylimidazo[1,2-a]Benzimidazole Dinitrate and Determination of the Main Metabolite in Blood Serum of Laboratory Animals

Urinary excretion of 9-(2-diethylaminoethyl)-2-phenylimidazo[1,2- a ]benzimidazole dinitrate after intragastric administration at a dose of 10 mg/kg has been studied in laboratory rats. The main metabolite in blood serum of rats was determined after a single intravenous injection at a dose of 10 mg/...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2022-11, Vol.56 (8), p.1027-1032
Main Authors: Mitrakova, D. O., Chernikov, M. V., Remezova, I. P., Bunyatyan, N. D., Morozov, A. V.
Format: Article
Language:English
Subjects:
Biological products
Medicine
Metabolites
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Online Access:Get full text
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Summary:Urinary excretion of 9-(2-diethylaminoethyl)-2-phenylimidazo[1,2- a ]benzimidazole dinitrate after intragastric administration at a dose of 10 mg/kg has been studied in laboratory rats. The main metabolite in blood serum of rats was determined after a single intravenous injection at a dose of 10 mg/kg. The metabolite was determined in urine samples using HPLC. Its structure was established using HPLC-MS. According to the results, the drug substance was excreted unchanged in small amounts (~0.01% of the administered dose) because it was metabolized. The main metabolite was found in rat plasma as early as 3 min after intravenous injection at a dose of 10 mg/kg.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-022-02747-3