IN/I-Iodosuccinimide as a Precatalyst for C–N Bond-Forming Reactions from Alcohols under Mild Reaction Conditions

We report an efficient and selective methodology for the direct cross-coupling of alcohols with N-nucleophiles mediated by N-iodosuccinimide (NIS) as the non-metal, commercially available, low-cost, and most effective precatalyst among the N-halosuccinimides (NXSs) under mild reaction conditions enh...

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Bibliographic Details
Published in:Catalysts 2022-11, Vol.12 (11)
Main Authors: Ajvazi, Njomza, Stavber, Stojan
Format: Article
Language:English
Subjects:
Alcohols
Online Access:Get full text
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Summary:We report an efficient and selective methodology for the direct cross-coupling of alcohols with N-nucleophiles mediated by N-iodosuccinimide (NIS) as the non-metal, commercially available, low-cost, and most effective precatalyst among the N-halosuccinimides (NXSs) under mild reaction conditions enhancing the green chemical profiles of these reactions. The scale-up procedure was accomplished with almost quantitative yield, verifying the presented method's synthetic applicability and potential for industrial application.
ISSN:2073-4344
2073-4344
DOI:10.3390/catal12111368