New Pyrroline Isolated from Antarctic Krill-Derived Actinomycetes INocardiopsis/I sp. LX-1 Combining with Molecular Networking

Antarctic krill (Euphausia superba) of the Euphausiidae family comprise one of the largest biomasses in the world and play a key role in the Antarctic marine ecosystem. However, the study of E. superba-derived microbes and their secondary metabolites has been limited. Chemical investigation of the s...

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Bibliographic Details
Published in:Marine drugs 2023-02, Vol.21 (2)
Main Authors: Shi, Ting, Li, Yan-Jing, Wang, Ze-Min, Wang, Yi-Fei, Wang, Bo, Shi, Da-Yong
Format: Article
Language:English
Subjects:
Actinomycetales
Analysis
Genetic aspects
Health aspects
Identification and classification
Plant metabolites
Online Access:Get full text
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Summary:Antarctic krill (Euphausia superba) of the Euphausiidae family comprise one of the largest biomasses in the world and play a key role in the Antarctic marine ecosystem. However, the study of E. superba-derived microbes and their secondary metabolites has been limited. Chemical investigation of the secondary metabolites of the actinomycetes Nocardiopsis sp. LX-1 (in the family of Nocardiopsaceae), isolated from E. superba, combined with molecular networking, led to the identification of 16 compounds a–p (purple nodes in the molecular network) and the isolation of one new pyrroline, nocarpyrroline A (1), along with 11 known compounds 2–12. The structure of the new compound 1 was elucidated by extensive spectroscopic investigation. Compound 2 exhibited broad-spectrum antibacterial activities against A. hydrophila, D. chrysanthemi, C. terrigena, X. citri pv. malvacearum and antifungal activity against C. albicans in a conventional broth dilution assay. The positive control was ciprofloxacin with the MIC values of
ISSN:1660-3397
1660-3397
DOI:10.3390/md21020127