Guidongnins I–J: Two New 6,7-Iseco/I-7,20-Olide-Ient/I-kaurene Diterpenes with Unusual Structures from IIsodon rubescens/I

Two undescribed ent-kaurene diterpenes, named guidongnins I (1) and J (2), were isolated from the medicinal plant Isodon rubescens. Compound 1 was determined to contain an unprecedented 23 carbons in the skeleton by bearing an extra isopropyl group at C-17 out of the diterpenoid parent structure, an...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-08, Vol.24 (17)
Main Authors: Zou, Juan, Ye, Jianghai, Zhao, Chenliang, Zhang, Jingjie, Liu, Yahua, Pan, Lutai, He, Kang, Zhang, Hongjie
Format: Article
Language:English
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Summary:Two undescribed ent-kaurene diterpenes, named guidongnins I (1) and J (2), were isolated from the medicinal plant Isodon rubescens. Compound 1 was determined to contain an unprecedented 23 carbons in the skeleton by bearing an extra isopropyl group at C-17 out of the diterpenoid parent structure, and compound 2 was the first example of 6,7-seco-7,20-olide-ent-kaurenes with two fused-tetrahydrofuran rings formed between C-6 and C-19/C-20 through oxygen bridges. Their structures, including their absolute configurations, were determined using the analyses of the spectroscopic and X-ray diffraction data. Guidongnins I (1) and J (2) were assessed for their anti-cancer activities against the growth of various cancer cell lines, and 2 displayed cytotoxic potency against HepG2 at IC[sub.50] 27.14 ± 3.43 μM.
ISSN:1422-0067
DOI:10.3390/ijms241713451