Cardiovascular risk in Cuban adolescents and young adults with congenital adrenal hyperplasia

• Published in: BMC Endocrine Disorders 2023, Vol.23 (1)
• Main Authors: Espinosa Reyes, Tania M, Pesántez Velepucha, Alba Katherine, Cabrera Rego, Julio Oscar, Valdés Gómez, Wendy, Domínguez Alonso, Emma, Falhammar, Henrik
• Format: Report
• Language: English
• Subjects: Adrenogenital syndrome; Atherosclerosis; Blood sugar; Care and treatment; Development and progression; Endothelium; Fludrocortisone; Genetic disorders; Hydroxyprogesterone; Hypercholesterolemia; Hypertension; Insulin resistance; Risk factors; Teenagers; Triglycerides; Type 2 diabetes; Youth
• ISSN: 1472-6823; 1472-6823
• DOI: 10.1186/s12902-023-01499-9

Background Hyperandrogenism and supraphysiologic glucocorticoid replacement may lead to subclinical atherosclerosis in people with congenital adrenal hyperplasia (CAH) and predispose the development of cardiovascular diseases from an early age. Objectives To determine if cardiometabolic risk factors and subclinical atherosclerosis are more frequent in patients with CAH due to 21-hydroxylase deficiency (21OHD) and if there is an association with clinical, hormonal and treatment of 21OHD. Material and methods A descriptive prospective cross-sectional study exploring clinical variables, biochemical, hormonal variables, endothelial dysfunction (flow-mediated dilation < 5%) and carotid intima media thickness ([greater than or equal to] 95 percentile in adolescents and [greater than or equal to] 75 percentile in adults) and epicardial fat. Adolescents and young patients with 21OHD were compared with controls matched by age, sex, body mass index and Tanner stage. Results Forty four subjects (22 with CAH), 36 (82%) females, with a mean age of 17.1 [+ or -] 5.5 years (range 10-30 years) were included. Family history revealed diabetes, hypertension, and hypercholesterolemia with high frequencies in both groups. The blood pressure was similar in both groups. Blood glucose levels were lower and triglycerides higher in patient (both p < 0.01). Epicardial fat was similar between groups and in patients with CAH it was related to cholesterol levels (r = 0.679, p < 0.01), time since CAH diagnosis (r = 0.462, p = 0.03) and glucocorticoid dose (r = 0.499, p = 0.04). Carotid intima media thickness (CIMT) had a tendency to be increased in patients (p = 0.07) and was directly related to 17-hydroxyprogesterone (r = 0.510, p = 0.018), diastolic blood pressure (r = 0.444, p = 0.04) and the homeostatic model assessment (HOMA) index (r = 0.507, p = 0.01). Endothelial dysfunction was not different between groups. Conclusions Some cardiometabolic risk factors were increased in patients with CAH and were associated with clinical, hormonal and treatment parameters of CAH. Cardiometabolic risk should be evaluated regularly in patients with CAH. Keywords: 21-hydroxylase deficiency, Endothelial dysfunction, Carotid intima media thickness, 17-hydroxyprogesterone, Blood pressure, Insulin resistance