Tuberculin skin test and Interferon-gamma release assay agreement, and associated factors with latent tuberculosis infection, in medical and nursing students in Bandung, Indonesia

Background No gold standard diagnostic test exists for latent tuberculosis infection (LTBI). The intra-dermal tuberculin skin test (TST) has known limitations and Interferon-gamma release assays (IGRA) have been developed as an alternative. We aimed to assess agreement between IGRA and TST, and risk...

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Bibliographic Details
Published in:PLoS ONE 2024, Vol.19 (3), p.e0299874
Main Authors: Apriani, Lika, McAllister, Susan, Sharples, Katrina, Aini, Isni Nurul, Nurhasanah, Hanifah, Ratnaningsih, Dwi Febni, Indrati, Agnes Rengga, Ruslami, Rovina, Alisjahbana, Bachti, van Crevel, Reinout, Hill, Philip C
Format: Report
Language:English
Subjects:
Care and treatment
Diagnosis
Evaluation
Health aspects
Interferon gamma
Tuberculin test
Tuberculosis
Online Access:Get full text
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Summary:Background No gold standard diagnostic test exists for latent tuberculosis infection (LTBI). The intra-dermal tuberculin skin test (TST) has known limitations and Interferon-gamma release assays (IGRA) have been developed as an alternative. We aimed to assess agreement between IGRA and TST, and risk factors for test positivity, in Indonesian healthcare students. Methods Medical and nursing students starting their clinical training were screened using IGRA and TST. Agreement between the two tests was measured using Cohen's Kappa coefficient. Logistic regression was used to identify factors associated with test positivity. Results Of 266 students, 43 (16.2%) were IGRA positive and 85 (31.9%) TST positive. Agreement between the two tests was 74.7% (kappa 0.33, 95% CI 0.21-0.45, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0299874