Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age

We aimed to study the mechanism behind worse coronavirus disease-19 (COVID-19) outcomes in men and whether the differences between sexes regarding mortality as well as disease severity are influenced by sex hormones. To do so, we used age as a covariate in the meta-regression and subgroup analyses....

Full description

Saved in:
Bibliographic Details
Published in:Brazilian Journal of Medical and Biological Research 2022, Vol.55 (1)
Main Authors: Fabiao, J, Sassi, B, Pedrollo, E.F, Gerchman, F, Kramer, C.K, Leitao, C.B, Pinto, L.C
Format: Report
Language:English
Subjects:
Health aspects
Medical research
Medicine, Experimental
Men
Sex factors in disease
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We aimed to study the mechanism behind worse coronavirus disease-19 (COVID-19) outcomes in men and whether the differences between sexes regarding mortality as well as disease severity are influenced by sex hormones. To do so, we used age as a covariate in the meta-regression and subgroup analyses. This was a systematic search and meta-analysis of observational cohorts reporting COVID-19 outcomes. The PubMed (Medline) and Cochrane Library databases were searched. The primary outcome was COVID-19-associated mortality and the secondary outcome was COVID-19 severity. The study was registered at PROSPERO: 42020182924. For mortality, men had a relative risk of 1.36 (95%CI: 1.17 to 1.59; [I.sup.2] 63%, P for heterogeneity
ISSN:0100-879X
DOI:10.1590/1414-431X2021e11711