Health-state utility of patients with HER2-positive breast cancer in Vietnam: A multicenter cross-sectional study

Background Patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer may have poor prognoses and short overall and disease-free survival. Most previous studies focused on assessing the quality of life and health-state utility of the general population of breast cancer pati...

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Bibliographic Details
Published in:PLoS ONE 2024, Vol.19 (5), p.e0303011
Main Authors: Luu, Tram Nguyen Nguyet, Dinh, Dai Xuan, Tran, Thinh Xuan, Tran, Thang Binh, Tran, Huong Thanh, Pham, Kiet Huy Tuan, Nguyen, Huong Thi Thanh
Format: Report
Language:English
Subjects:
Analysis
Antimitotic agents
Antineoplastic agents
Breast cancer
Cancer
Cancer patients
Cost benefit analysis
Epidermal growth factor
Metastasis
Oncology, Experimental
Prognosis
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Summary:Background Patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer may have poor prognoses and short overall and disease-free survival. Most previous studies focused on assessing the quality of life and health-state utility of the general population of breast cancer patients. The number of studies for HER2-positive breast cancer patients is negligible. This study investigated the health-state utility and its associated factors among Vietnamese patients with HER2-positive breast cancer. Methods We conducted face-to-face interviews with 301 HER2-positive breast cancer patients to collect data. Their health-state utility was measured via the EQ-5D-5L instrument. The Mann-Whitney U and Kruskal-Wallis tests were employed to compare the differences in utility scores between two groups and among three groups or more, respectively. Factors associated with patients' heath-state utility were identified via Tobit regression models. Results Pain/discomfort (56.1%) and anxiety/depression (39.5%) were the two issues that patients suffered from the most, especially among metastatic breast cancer patients. The severity of distress (depression, anxiety, and stress) in patients was relatively mild. Of 301 patients, their average utility score was 0.86±0.17 (range: 0.03-1.00), and the average EQ-visual analogue scale (VAS) score was 69.12±12.60 (range: 30-100). These figures were 0.79±0.21 and 65.20±13.20 for 102 metastatic breast cancer patients, significantly lower than those of 199 non-metastatic cancer patients (0.89±0.13 and 71.13±11.78) (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0303011