Effects of Bisphenol A on Male Gonadal Tissue of Viviparous Fish: Histopathological Evidence in Goodea atripinnis/Efectos del Bisfenol A en tejido Gonadal Masculino de Peces Viviparos: Evidencia Histopatologica en Goodea atripinnis

• Published in: International journal of morphology 2024-07, Vol.42 (4), p.977
• Main Authors: Cervantes-Camacho, Isabel, Arturo Ruiz-Picos, Ricardo, Lopez-Lopez, Eugenia
• Format: Article
• Language: Spanish
• ISSN: 0717-9367

BPA is a multifunctional endocrine disruptor with ubiquitous presence in aquatic ecosystems. The Mexican Central Plateau is an area severely impacted by pollution, inhabited by endemic viviparous fish. However, efforts to understand the effects of BPA on native species such as Goodea atripinnis are non-existent. This study focused on providing in vivo evidence of alterations in the testes of G. atripinnis males due to acute exposure to BPA at test concentrations of 1 mg/L, 10 mg/L, and 50 mg/L for 96 h. BPA exposition 1 mg/L and 10 mg/L showed degeneration and disorganization in germinal tissue. Furthermore, there was a notable decrease in sperm within the seminiferous tubules of males exposed to 10 mg/L of BPA. In all treatments, somatic cells had alterations by connective tissue thickening and an increase in collagen fibers. Additionally, inflammation and bleeding occurred in the testes of males exposed to 1 and 10 mg/L BPA. The alterations in the testes of G. atripinnis are related to BPA toxicity, which can lead to apoptosis in germ cells increasing connective tissue. Finally, even though the changes produced by BPA became evident in acute exposure (96 h), its effects are probably irreversible, compromising the reproduction of G. atripinnis. KEY WORDS: Biomarker; Testes; Endocrine disruptor; Viviparous fish; Emerging pollutant. El BPA es un disruptor endocrino multifuncional con presencia ubicua en los ecosistemas acuaticos. La Meseta Central mexicana habitada por peces viviparos endemicos, es una zona severamente impactada por la contaminacion. Sin embargo, los esfuerzos por comprender los efectos del BPA en especies nativas como Goodea atripinnis son inexistentes. Este estudio se centro en proporcionar evidencia in vivo de alteraciones en los testiculos de machos de G. atripinnis debido a la exposicion aguda al BPA en concentraciones de prueba de 1 mg/L, 10 mg/L y 50 mg/L durante 96 h. La exposicion a BPA 1 mg/L y 10 mg/L mostro degeneracion y desorganizacion en el tejido germinal. Ademas, hubo una disminucion notable de los espermatozoides dentro de los tubulos seminiferos de machos expuestos a 10 mg/L de BPA. En todos los tratamientos las celulas somaticas presentaron alteraciones por engrosamiento del tejido conectivo y aumento de las fibras de colageno. Ademas, se produjo inflamacion y sangrado en los testiculos de machos expuestos a 1 y 10 mg/L de BPA. Las alteraciones en los testiculos de G. atripinnis estan relacionadas con la toxicidad del BP